Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 9/20 | 0.35 |
| ▸ | HTR2C | P28335 | 9/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28947182 | 0.82 | KAT2B (0.31) | — | |
| SCHEMBL18716783 | 0.77 | LMNA (0.37) | HTR2AHTR2CL3MBTL1LMNAKDM4E | |
| SCHEMBL6783474 | 0.76 | — | — | |
| SCHEMBL5552015 | 0.73 | POLB (0.41) | POLBMEN1KMT2ANCF1 | |
| SCHEMBL46703 | 0.71 | L3MBTL3 (0.42) | HTR2AHTR2CL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL8442130 | 0.71 | HTR2A (0.41) | HTR2AHTR2CL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL24083946 | 0.70 | ADH1C (0.39) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7727423 | 0.70 | ADH1C (0.39) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL28140784 | 0.70 | ALDH1A1 (0.39) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL24329483 | 0.70 | ADH1C (0.39) | KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451802-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | Pathway Therapeutics, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005119-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2011-01-13 | — | — | WO | disclosed |