Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | SHBG | P04278 | 4/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348134 | 1.00 | LMNA (0.62) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL9348215 | 1.00 | LMNA (0.62) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL11117577 | 0.90 | NR3C1 (0.67) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL11117579 | 0.90 | NR3C1 (0.67) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL10938509 | 0.90 | NR3C1 (0.67) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL24476232 | 0.88 | SHBG (0.64) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL24476209 | 0.88 | SHBG (0.64) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL10820974 | 0.88 | LMNA (0.60) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL10820973 | 0.88 | LMNA (0.60) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL10821129 | 0.88 | LMNA (0.60) | LMNASHBGNR3C1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375349-B1 | Phosphinic acid substituted steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0375351-B1 | Phosphonic acid substituted steroids as steroid 5alpha-reductase inhibitors | SMITHKLINE BEECHAM CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0289327-B1 | STEROID 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-18 | — | — | EP | disclosed |
| US-5026882-A | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-25 | — | — | US | disclosed |
| US-5017568-A | Enzyme inhibitors, carboxylation | SMITHKLINE BEECHAM CORPORATION (US) | 1991-05-21 | — | — | US | disclosed |
| US-4946834-A | ACRYLATE ANALOGUES OF STEROIDAL SYNTHETIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0375351-A1 | Phosphonic acid substituted steroids as steroid 5alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0375349-A1 | Phosphinic acid substituted steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |
| US-4910226-A | Estrane compound | SMITHKLINE BECKMAN CORPORATION (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0289327-A2 | Steroid 5-alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |