Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | CNOT7 | Q9UIV1 | 8/20 | 0.41 |
| ▸ | PARN | O95453 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9350658 | 0.88 | CNOT7 (0.43) | PDE4APDE4BPDE4CPDE4DCNOT7 | |
| SCHEMBL27537551 | 0.82 | GRIN1 (0.43) | CNOT7PARNGRIN1GRIN2B | |
| SCHEMBL10694966 | 0.81 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL17682308 | 0.81 | CNOT7 (0.39) | CNOT7PARNGRIN1GRIN2BLMNA | |
| SCHEMBL17682309 | 0.81 | CNOT7 (0.39) | CNOT7PARNGRIN1GRIN2BLMNA | |
| SCHEMBL7403404 | 0.80 | ALDH1A1 (0.57) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10696644 | 0.80 | ADORA2B (0.65) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL11078954 | 0.80 | ADORA2B (0.48) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL21861597 | 0.79 | TRPA1 (0.59) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10696193 | 0.79 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | disclosed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | disclosed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |