Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | MYT1 | Q01538 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16228010 | 0.84 | PIM1 (0.57) | PIM1PARP1KDM4EMAPTCCNC | |
| SCHEMBL14610232 | 0.82 | PIM1 (0.68) | PIM1PARP1KDM4ECCNCCDK8 | |
| SCHEMBL21441804 | 0.79 | PARP1 (0.59) | PIM1PARP1KDM4EMAPTCCNC | |
| SCHEMBL3999989 | 0.76 | NOS3 (0.46) | PIM1KDM4ENNMTPKMYT1DGAT1 | |
| SCHEMBL12488275 | 0.75 | PIM1 (0.42) | PIM1MAPTNNMTPKMYT1DGAT1 | |
| SCHEMBL16228335 | 0.74 | OPRK1 (0.59) | PIM1KDM4EMAPTPKMYT1RAB9A | |
| SCHEMBL15093819 | 0.74 | PIM1 (0.46) | PIM1PARP1KDM4EMAPTCCNC | |
| Hydrochloric Acid SCHEMBL28633319 | 0.73 | PIM1 (0.41) | PIM1KDM4EMAPK1NNMTPKMYT1 | |
| SCHEMBL31507586 | 0.73 | PIM1 (0.41) | PIM1KDM4ENNMTPKMYT1DGAT1 | |
| SCHEMBL26684509 | 0.73 | PIM1 (0.41) | PIM1KDM4ENNMTPKMYT1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | claimed |
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |