Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | PKMYT1 | Q99640 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16232861 | 0.84 | KDM4E (0.50) | PIM1KDM4ERAB9AMAPTTDP1 | |
| SCHEMBL935079 | 0.84 | PIM1 (0.54) | PIM1KDM4ERAB9AMAPTTDP1 | |
| SCHEMBL16228213 | 0.84 | KDM4E (0.68) | PIM1KDM4ERAB9AMAPTTDP1 | |
| SCHEMBL14610232 | 0.80 | PIM1 (0.68) | PIM1KDM4EPARP1KMT2ALCK | |
| SCHEMBL16228012 | 0.79 | KDM4E (0.46) | PIM1KDM4ERAB9AMAPTTDP1 | |
| SCHEMBL21441804 | 0.78 | PARP1 (0.59) | PIM1KDM4ERAB9AMAPTPARP1 | |
| SCHEMBL3956008 | 0.77 | PIM1 (0.57) | PIM1ALDH1A1 | |
| SCHEMBL16228335 | 0.76 | OPRK1 (0.59) | PIM1KDM4ERAB9AMAPTTDP1 | |
| SCHEMBL3999989 | 0.75 | NOS3 (0.46) | PIM1KDM4ETDP1KMT2ALMNA | |
| SCHEMBL3956011 | 0.73 | PIM1 (0.51) | PIM1KDM4ERAB9AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140336221-A1 | Antibiotic and Anti-Parasitic Agents that Modulate Class II Fructose 1, 6-Bisphosphate Aldolase | COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER (US) | 2014-11-13 | — | — | US | claimed |
| US-9394254-B2 | Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase | The University of Denver and Regis University (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394254-B2 | Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase | The University of Denver and Regis University (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394254-B2 | Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase | The University of Denver and Regis University (US) | 2016-07-19 | — | — | US | disclosed |
| EP-2994142-A1 | ANTIBIOTIC AND ANTI-PARASITIC AGENTS THAT MODULATE CLASS II FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE | Colorado Seminary, Which Owns and Operates The University of Denver (US) | 2016-03-16 | — | — | EP | disclosed |
| US-20140336221-A1 | Antibiotic and Anti-Parasitic Agents that Modulate Class II Fructose 1, 6-Bisphosphate Aldolase | COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336221-A1 | Antibiotic and Anti-Parasitic Agents that Modulate Class II Fructose 1, 6-Bisphosphate Aldolase | COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336221-A1 | Antibiotic and Anti-Parasitic Agents that Modulate Class II Fructose 1, 6-Bisphosphate Aldolase | COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER (US) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336221-A1 | Antibiotic and Anti-Parasitic Agents that Modulate Class II Fructose 1, 6-Bisphosphate Aldolase | ALDOA, DERA, FBP1 | PIM1 3196/4885KDM4E 718/4885RAB9A 2894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.