Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458626 | 1.00 | CYP3A4 (0.54) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL5451605 | 1.00 | CYP3A4 (0.54) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL9356129 | 0.95 | CYP3A4 (0.57) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL8304218 | 0.95 | CYP3A4 (0.57) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL8304211 | 0.95 | CYP3A4 (0.57) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL8304214 | 0.95 | CYP3A4 (0.57) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL23043376 | 0.88 | FKBP1A (0.53) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL9347282 | 0.88 | FKBP1A (0.53) | CYP3A4KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL9356296 | 0.87 | CHRM2 (0.50) | KMT2AL3MBTL1 | |
| SCHEMBL9352549 | 0.87 | CHRM2 (0.50) | KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299513-B1 | Azetidine derivatives, compositions and their use | FIDIA GEORGETOWN INST (US) | 1994-10-05 | — | — | EP | disclosed |
| US-4990504-A | Modulate excitatory amino acid receptor system | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1991-02-05 | — | — | US | disclosed |
| US-4946839-A | ALZHEIMER'S DISEASE | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0299513-A1 | Azetidine derivatives, compositions and their use | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1989-01-18 | — | — | EP | disclosed |