Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.61 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.61 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.61 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.61 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.61 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.61 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.61 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9353088 | 1.00 | SLC6A3 (0.61) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Maleic Acid SCHEMBL9353012 | 0.96 | SLC6A3 (0.68) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9356803 | 0.88 | CHRM1 (0.59) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9356810 | 0.88 | CHRM1 (0.59) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9357093 | 0.83 | CHRM2 (0.64) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9353352 | 0.83 | HRH1 (0.44) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9353367 | 0.83 | HRH1 (0.44) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9352958 | 0.80 | BCHE (0.57) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9352967 | 0.80 | BCHE (0.57) | SLC6A3CYP2D6CHRM2HTR1AADRA2A | |
| Fumaric Acid SCHEMBL9356787 | 0.80 | DRD3 (0.62) | SLC6A3CYP2D6CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399414-B1 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5153207-A | Antihistamine and antiallergic agent | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| EP-0399414-A1 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-11-28 | — | — | EP | disclosed |