Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PAM | P19021 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | POLA1 | P09884 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 3/20 | 0.37 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20261931 | 0.87 | DGKA (0.52) | DGKALMNAPAMMAPTMAPK1 | |
| SCHEMBL28513665 | 0.85 | DGKA (0.41) | DGKACA12CA2CA7CA9 | |
| SCHEMBL28508425 | 0.83 | FAAH (0.49) | LMNAMAPTPOLBKDM4EDUSP3 | |
| SCHEMBL28414023 | 0.81 | DGKA (0.38) | DGKACA12CA2CA7CA9 | |
| SCHEMBL6640832 | 0.81 | DGKA (0.53) | DGKALMNAPAMMAPTMAPK1 | |
| SCHEMBL28363537 | 0.81 | FAAH (0.46) | CA12CA2CA7CA9CA14 | |
| SCHEMBL28270544 | 0.78 | DGKA (0.50) | DGKACA12CA2CA7CA9 | |
| SCHEMBL1960961 | 0.78 | DGKA (0.53) | DGKALMNAPAMMAPTMAPK1 | |
| SCHEMBL11558967 | 0.78 | DGKA (0.53) | DGKALMNAPAMMAPTMAPK1 | |
| SCHEMBL1962326 | 0.78 | DGKA (0.53) | DGKALMNAPAMMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473234-A2 | COSMETIC CONTAINING PURINE AND/OR A PURINE DERIVATIVE AND SCLAREOL | Henkel AG & Co. KGaA (DE) | 2012-07-11 | — | — | EP | disclosed |
| EP-2473236-A2 | USE OF PURINE AND/OR A PURINE DERIVATIVE AND AT LEAST ONE OLIGONUCLEOTIDE TO INFLUENCE THE NATURAL PIGMENTATION PROCESS | Henkel AG & Co. KGaA (DE) | 2012-07-11 | — | — | EP | disclosed |
| EP-2456417-A2 | USE OF CARNITINE AND DIHYDROQUERCITIN TO POSITIVELY INFLUENCE THE NATURAL PIGMENTATION PROCESS | Henkel AG & Co. KGaA (DE) | 2012-05-30 | — | — | EP | disclosed |
| EP-2456418-A2 | USE OF DIHYDROQUERCETIN AND AT LEAST ONE AMINO ACID TO POSITIVELY INFLUENCE THE NATURAL PIGMENTATION PROCESS | Henkel AG & Co. KGaA (DE) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011009758-A2 | USE OF PURINE AND/OR A PURINE DERIVATIVE AND AT LEAST ONE OLIGONUCLEOTIDE TO INFLUENCE THE NATURAL PIGMENTATION PROCESS | HENKEL AG & CO. KGAA (DE) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009761-A2 | USE OF CARNITINE AND DIHYDROQUERCITIN TO POSITIVELY INFLUENCE THE NATURAL PIGMENTATION PROCESS | HENKEL AG & CO. KGAA (DE) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009759-A2 | USE OF DIHYDROQUERCETIN AND AT LEAST ONE AMINO ACID TO POSITIVELY INFLUENCE THE NATURAL PIGMENTATION PROCESS | HENKEL AG & CO. KGAA (DE) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009757-A2 | USE OF HUMAN BETA-DEFENSIN TO INFLUENCE THE NATURAL PIGMENTATION PROCESS | HENKEL AG & CO. KGAA (DE) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009760-A1 | USE OF AN ACTIVE SUBSTANCE OF ECHINACEA TO INFLUENCE THE NATURAL PIGMENTATION PROCESS | HENKEL AG & CO. KGAA (DE) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009763-A2 | COSMETIC CONTAINING PURINE AND/OR A PURINE DERIVATIVE AND SCLAREOL | HENKEL AG & CO. KGAA (DE) | 2011-01-27 | — | — | WO | disclosed |