Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ACP3 | P15309 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4941532 | 0.85 | MEN1 (0.55) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL6865758 | 0.82 | MEN1 (0.62) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL21294760 | 0.82 | ACP3 (0.51) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL29935522 | 0.81 | MEN1 (0.65) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL11808569 | 0.81 | MEN1 (0.60) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL378581 | 0.81 | MEN1 (0.65) | MEN1KMT2AMAPTACP3HDAC1 | |
| Hydrochloric Acid SCHEMBL2525493 | 0.79 | MEN1 (0.63) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL265041 | 0.79 | MEN1 (0.59) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL6710664 | 0.79 | MEN1 (0.59) | MEN1KMT2AMAPTACP3HDAC1 | |
| SCHEMBL30496803 | 0.79 | EPHX1 (0.59) | MEN1KMT2AMAPTACP3SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454239-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | Janssen Pharmaceuticals Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011006903-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2011-01-20 | — | — | WO | disclosed |
| EP-1926722-A1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | Novartis AG (CH) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007030377-A1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-03-15 | — | — | WO | disclosed |