Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9356497 | 0.86 | CYSLTR2 (0.43) | HDAC1HDAC8SIRT2SIRT1CYSLTR2 | |
| SCHEMBL9356843 | 0.82 | BID (0.49) | HDAC1CYSLTR2CYSLTR1 | |
| SCHEMBL10445309 | 0.82 | BID (0.49) | HDAC1CYSLTR2CYSLTR1 | |
| SCHEMBL9356490 | 0.82 | BID (0.49) | HDAC1CYSLTR2CYSLTR1 | |
| SCHEMBL9356869 | 0.82 | CYSLTR2 (0.53) | LIPGCYSLTR2CYSLTR1 | |
| SCHEMBL9356850 | 0.82 | BID (0.49) | HDAC1CYSLTR2CYSLTR1 | |
| SCHEMBL9356495 | 0.82 | BID (0.49) | HDAC1CYSLTR2CYSLTR1 | |
| SCHEMBL9360562 | 0.82 | HDAC1 (0.46) | HDAC1HDAC8GAANR3C2MAOB | |
| SCHEMBL9356518 | 0.78 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1MEN1KMT2A | |
| SCHEMBL9360639 | 0.78 | ALDH1A1 (0.40) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0403250-B1 | Phenylglycidamides useful for preparing alpha-hydroxy-beta-sulfido-arylpropionic acid derivatives | SMITHKLINE BEECHAM CORP (US) | 1994-11-23 | — | — | EP | disclosed |
| EP-0403250-A2 | Phenylglycidamides useful for preparing alpha-hydroxy-beta-sulfido-arylpropionic acid derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |