Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | ACR | P10323 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166082 | 0.90 | LMNA (0.64) | LMNAPRSS1ACRALDH1A1KMT2A | |
| SCHEMBL8998922 | 0.90 | LMNA (0.64) | LMNAPRSS1ACRALDH1A1KMT2A | |
| SCHEMBL8998925 | 0.90 | LMNA (0.64) | LMNAPRSS1ACRALDH1A1KMT2A | |
| SCHEMBL1485799 | 0.85 | PARP10 (0.52) | LMNAPRSS1ACRKMT2AATM | |
| SCHEMBL17695796 | 0.82 | LMNA (0.55) | LMNAALDH1A1KMT2AGAAPKM | |
| SCHEMBL2221244 | 0.82 | PARP10 (0.46) | LMNAPRSS1ALDH1A1KMT2AGAA | |
| SCHEMBL27416289 | 0.82 | LMNA (0.55) | LMNAPRSS1ACRALDH1A1KMT2A | |
| SCHEMBL7459980 | 0.82 | PARP10 (0.46) | ALDH1A1KMT2AGAAMEN1TDP1 | |
| SCHEMBL28894207 | 0.82 | LMNA (0.55) | LMNAALDH1A1KMT2AGAAPKM | |
| SCHEMBL27657141 | 0.82 | LMNA (0.55) | LMNAPRSS1ACRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160297828-A1 | SPIROCYCLIC COMPOUNDS CONTAINING SPIRO[INDOLYL-3,1'-PYRROLO[3,4-C]PYRROLE] CORE AND SULPHUR-CONTAINING AMINO ACID RESIDUES | ZAGORII GLEB VLADIMIROVICH (UA) | 2016-10-13 | — | — | US | disclosed |
| EP-0393713-B1 | Process for the preparation of N-substituted maleimides | TOSOH CORP (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5087705-A | Heating N-substituted maleamic acid monoester in presence of acid catalyst | SHIN-DAIKYOWA PETROCHEMICAL CO., LTD. (JP) | 1992-02-11 | — | — | US | disclosed |
| EP-0393713-A1 | Process for the preparation of N-substituted maleimides | Tosoh Corporation (JP) | 1990-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297828-A1 | SPIROCYCLIC COMPOUNDS CONTAINING SPIRO[INDOLYL-3,1'-PYRROLO[3,4-C]PYRROLE] CORE AND SULPHUR-CONTAINING AMINO ACID RESIDUES | CRHR1, NR3C1, MC2R | LMNA 3563/4885DDAH1 1376/4885PRSS1 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.