Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cariporide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A known ✓ | P37088 | 12/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | THPO | P40225 | 3/20 | 0.48 |
| ▸ | GMNN | O75496 | 3/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.46 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cariporide SCHEMBL39639 | 0.84 | SLC9A1 (0.61) | SLC9A1SLC9A2 | |
| Cariporide SCHEMBL221094 | 0.83 | SLC9A1 (0.63) | SLC9A1SLC9A2 | |
| Cariporide SCHEMBL6261845 | 0.83 | SLC9A1 (0.63) | SLC9A1SLC9A2 | |
| Cariporide SCHEMBL220085 | 0.83 | SLC9A1 (0.60) | SLC9A1SLC9A2 | |
| Cariporide SCHEMBL1229789 | 0.83 | SLC9A1 (0.60) | SLC9A1SLC9A2 | |
| Amiloride SCHEMBL28404348 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| Amiloride SCHEMBL29039882 | 0.76 | SCNN1A (0.52) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| Amiloride SCHEMBL3253482 | 0.76 | SCNN1A (0.57) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| Amiloride SCHEMBL28595428 | 0.75 | ALDH1A1 (0.55) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 | |
| Amiloride SCHEMBL15517241 | 0.75 | SCNN1A (0.58) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453897-A1 | COMBINATION OF A SODIUM-PROTON EXCHANGER INHIBITOR AND OF A DIHYDRO-1,3,5-TRIAZINE AMINE DERIVATIVE | Merck Patent GmbH (DE) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011006573-A1 | COMBINATION OF A SODIUM-PROTON EXCHANGER INHIBITOR AND OF A DIHYDRO-1,3,5-TRIAZINE AMINE DERIVATIVE | MERCK PATENT GMBH (DE) | 2011-01-20 | — | — | WO | disclosed |