Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791965 | 0.76 | P2RX3 (0.53) | KDM4EHPGDNPC1POLBRAB9A | |
| SCHEMBL18495300 | 0.75 | HPGD (0.51) | KDM4EHPGDNPC1POLBRAB9A | |
| SCHEMBL166484 | 0.74 | LMNA (0.82) | KDM4EHPGDNPC1POLBRAB9A | |
| SCHEMBL10095302 | 0.74 | VNN1 (0.62) | KDM4EHPGDNPC1POLBRAB9A | |
| SCHEMBL25412037 | 0.74 | PDE10A (0.60) | KDM4EHPGDNPC1RAB9APDE10A | |
| Hydrochloric Acid SCHEMBL27843329 | 0.73 | LMNA (0.80) | KDM4EHPGDNPC1POLBRAB9A | |
| SCHEMBL9733209 | 0.72 | PDE10A (0.62) | KDM4EPOLBPDE10AGAAKMT2A | |
| SCHEMBL7723002 | 0.72 | HTT (0.67) | HPGDNPC1POLBRAB9AGAA | |
| SCHEMBL6006695 | 0.71 | PDE10A (0.56) | KDM4EHPGDPOLBPDE10AGAA | |
| SCHEMBL5709396 | 0.71 | PDE10A (0.67) | KDM4EHPGDNPC1RAB9APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373891-B1 | Anti-tumour agents | ICI PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| EP-0373891-A2 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-20 | — | — | EP | disclosed |