Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6287035 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2SMYD3KMT2A | |
| SCHEMBL9367565 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2SMYD3KMT2A | |
| SCHEMBL9366168 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2SMYD3KMT2A | |
| SCHEMBL13417634 | 0.75 | EPHX2 (0.44) | ALDH1A1MAPTSMN1; SMN2SMYD3MAPK1 | |
| SCHEMBL9366701 | 0.74 | PKM (0.41) | ALDH1A1MAPTSMN1; SMN2SMYD3RAB9A | |
| SCHEMBL6219737 | 0.73 | ALDH1A1 (0.40) | ALDH1A1MAPTSMN1; SMN2GAASMYD3 | |
| SCHEMBL8524839 | 0.72 | MAPT (0.39) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9371968 | 0.72 | RARB (0.43) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL8525367 | 0.70 | SMN1; SMN2 (0.38) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9376059 | 0.67 | BRD4 (0.47) | ALDH1A1SMN1; SMN2SMYD3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409435-B1 | Heteroaryl piperazine antipsychotic agents | PFIZER (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5350747-A | Heteroaryl piperazine antipsychotic agents | PFIZER INC (US) | 1994-09-27 | — | — | US | disclosed |
| WO-1991000863-A1 | HETEROARYL PIPERAZINE ANTIPSYCHOTIC AGENTS | PFIZER INC. (US) | 1991-01-24 | — | — | WO | disclosed |