Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 15/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367738 | 0.82 | APP (0.36) | APPNR4A2RXRARXRBKDM4E | |
| SCHEMBL3426875 | 0.80 | AGXT (0.32) | APP | |
| SCHEMBL663356 | 0.79 | DUT (0.37) | APPKDM4EALDH1A1 | |
| SCHEMBL8449995 | 0.79 | L3MBTL1 (0.47) | — | |
| SCHEMBL8449993 | 0.79 | LTA4H (0.43) | NR4A2RXRARXRB | |
| SCHEMBL4496052 | 0.78 | PREP (0.48) | APPNR4A2RXRARXRB | |
| SCHEMBL4959621 | 0.78 | DUT (0.39) | APPALDH1A1 | |
| SCHEMBL26185849 | 0.78 | MAOB (0.54) | APP | |
| SCHEMBL9127930 | 0.77 | ALDH1A1 (0.42) | APPKDM4EALDH1A1 | |
| SCHEMBL3012099 | 0.76 | CYP3A4 (0.50) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594588-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1994-05-04 | — | — | EP | disclosed |
| WO-1991013054-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | PFIZER LIMITED (GB) | 1991-09-05 | — | — | WO | disclosed |