Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 2/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253816 | 0.77 | ALDH1A1 (0.41) | LMNAHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL4875739 | 0.76 | LMNA (0.53) | LMNAHSD17B10ALDH1A1HDAC3HDAC4 | |
| Benzophenone SCHEMBL27761907 | 0.76 | LMNA (0.57) | LMNAHSD17B10ALDH1A1HDAC3HDAC4 | |
| SCHEMBL17115020 | 0.76 | NOS3 (0.47) | LMNAHSD17B10ALDH1A1CRHBPCRHR2 | |
| SCHEMBL9285950 | 0.75 | CYP3A4 (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL25644878 | 0.75 | MEN1 (0.49) | LMNAHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL27425745 | 0.75 | MEN1 (0.47) | LMNAHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL10910457 | 0.75 | LMNA (0.51) | LMNAHSD17B10ALDH1A1HDAC3HDAC4 | |
| SCHEMBL13177046 | 0.74 | LMNA (0.55) | LMNAHSD17B10ALDH1A1HDAC3HDAC4 | |
| SCHEMBL50454 | 0.73 | LMNA (0.80) | LMNAHSD17B10ALDH1A1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346791-B1 | 1,2-diarylethylamines for treatment of neurotoxic injury | SEARLE & CO (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0346791-A1 | 1,2-diarylethylamines for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1989-12-20 | — | — | EP | disclosed |