Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366970 | 1.00 | ATM (0.32) | ATMMEN1KMT2AHDAC2HDAC8 | |
| SCHEMBL6693798 | 0.72 | EPHX2 (0.38) | ATMMEN1KMT2AHDAC2HDAC8 | |
| SCHEMBL5908164 | 0.72 | CYP1A2 (0.45) | ALDH1A1 | |
| SCHEMBL7650386 | 0.70 | CNR2 (0.42) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL31285850 | 0.68 | KMT2A (0.42) | MEN1KMT2AEPHX2HSD17B3ALDH1A1 | |
| SCHEMBL8793695 | 0.68 | KMT2A (0.42) | MEN1KMT2AEPHX2HSD17B3ALDH1A1 | |
| SCHEMBL6690571 | 0.68 | BRPF1 (0.35) | MEN1KMT2AHDAC2HDAC8HDAC6 | |
| SCHEMBL6175819 | 0.65 | PTGS1 (0.42) | HDAC2HDAC8HDAC6EPHX2HSD17B3 | |
| SCHEMBL7413032 | 0.64 | MMP1 (0.36) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7417802 | 0.64 | SMN1; SMN2 (0.51) | MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449523-B1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | SQUIBB & SONS INC (US) | 1994-08-17 | — | — | EP | disclosed |