Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 6/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343373 | 0.82 | ALDH1A1 (0.55) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL4258349 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL18040253 | 0.79 | TNFSF11 (0.56) | ALDH1A1KDM4ETNFSF11MAOAHTT | |
| SCHEMBL29788060 | 0.77 | MAOA (0.57) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL2761994 | 0.77 | ALDH1A1 (0.59) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL14635823 | 0.76 | MAOA (0.42) | ALDH1A1KDM4EUSP2USP8USP7 | |
| SCHEMBL10541124 | 0.74 | AR (0.47) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL7980232 | 0.72 | KDM4E (0.46) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL82833 | 0.72 | ALDH1A1 (0.55) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL10537256 | 0.72 | TRPV4 (0.47) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |