Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA6 | P23280 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31192163 | 0.79 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDCA1CA2 | |
| SCHEMBL7980286 | 0.79 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDCA1CA2 | |
| Methane SCHEMBL28300119 | 0.78 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDCA1CA2 | |
| SCHEMBL27238703 | 0.78 | CHEK1 (0.42) | KDM4EALDH1A1CA1CA2CA4 | |
| SCHEMBL7981630 | 0.77 | MAPT (0.75) | KDM4EALDH1A1CA1CA2CA4 | |
| SCHEMBL28305794 | 0.71 | PTGS2 (0.46) | KDM4EALDH1A1HPGDCA1CA2 | |
| SCHEMBL1512500 | 0.71 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDCA1CA2 | |
| SCHEMBL28233767 | 0.70 | DPP4 (0.41) | KDM4EALDH1A1CA1CA2CA4 | |
| Ammonia Solution, Strong SCHEMBL5558664 | 0.70 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL3158365 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1HPGDMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |