Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9376098 | 0.99 | MAPK14 (0.46) | MAPK14TP53MAPTKDM4EALDH1A1 | |
| Bromide SCHEMBL9368207 | 0.82 | TGFBR1 (0.43) | MAPK14KDM4ENPC1TGFBR1 | |
| SCHEMBL7693026 | 0.74 | NPC1 (0.49) | MAPK14TP53MAPTKDM4EALDH1A1 | |
| SCHEMBL13506384 | 0.72 | KDM4E (0.50) | TP53MAPTKDM4EALDH1A1ADORA2A | |
| SCHEMBL12844164 | 0.71 | ALDH1A1 (0.55) | TP53MAPTALDH1A1 | |
| SCHEMBL11463722 | 0.70 | IDO1 (0.57) | TP53MAPTKDM4EALDH1A1APOBEC3G | |
| SCHEMBL29078801 | 0.69 | KDM4E (0.53) | MAPK14KDM4EALDH1A1APOBEC3GADORA2A | |
| SCHEMBL7844784 | 0.69 | TGFBR1 (0.44) | MAPK14KDM4EALDH1A1NPC1TGFBR1 | |
| SCHEMBL9923202 | 0.69 | KDM4E (0.62) | TP53MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL18230383 | 0.69 | ALDH1A1 (0.55) | MAPTKDM4EALDH1A1NPC1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625151-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015071-A1 | THIAZOLYL-PYRIDINE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |