Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.55 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.42 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15996541 | 0.94 | CYP51A1 (0.50) | CYP51A1AOC3TSHRRECQLKCNH2 | |
| SCHEMBL10585881 | 0.75 | TAAR1 (0.47) | AOC3KCNH2TAAR1SLC6A2SLC6A3 | |
| SCHEMBL2032753 | 0.75 | ALDH1A1 (0.46) | ALDH1A1MAPT | |
| SCHEMBL4161150 | 0.70 | SLC6A2 (0.61) | KCNH2ALDH1A1LMNAMAPTSLC6A4 | |
| SCHEMBL4158699 | 0.70 | SLC6A2 (0.61) | KCNH2ALDH1A1LMNAMAPTSLC6A4 | |
| SCHEMBL2424315 | 0.70 | SLC6A2 (0.61) | KCNH2ALDH1A1LMNAMAPTSLC6A4 | |
| SCHEMBL3062170 | 0.70 | AOC3 (0.69) | AOC3ALDH1A1MAPTTAAR1CNR2 | |
| SCHEMBL436099 | 0.70 | AOC3 (0.52) | AOC3KCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL22461658 | 0.69 | AOC3 (0.43) | AOC3TSHRRECQLKCNH2ALDH1A1 | |
| SCHEMBL22421588 | 0.69 | AOC3 (0.43) | AOC3TSHRRECQLKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822727-B2 | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | ARENA PHARMACEUTICALS, INC. (US) | 2014-09-02 | — | — | US | claimed |
| JP-2011513402-A | — | — | 2011-04-28 | — | — | JP | claimed |
| EP-2288585-A1 | PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE | Arena Pharmaceuticals, Inc. (US) | 2011-03-02 | — | — | EP | claimed |
| US-20110015438-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE | ARENA PHARMACEUTICALS, INC. | 2011-01-20 | — | — | US | claimed |
| WO-2009111004-A1 | PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE | ARENA PHARMACEUTICALS, INC. (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2014202765-A1 | PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES | LEK PHARMACEUTICALS D.D. (SI) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014173928-A1 | NOVEL SYNTHETIC PROCESS TO 8-CHLORO-1-METHYL-BENZO[D]AZEPINE, NOVEL INTERMEDIATES AND THE PRODUCTION THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2014-10-30 | — | — | WO | disclosed |
| US-8822727-B2 | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | ARENA PHARMACEUTICALS, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822727-B2 | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | ARENA PHARMACEUTICALS, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| EP-2288585-A1 | PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE | Arena Pharmaceuticals, Inc. (US) | 2011-03-02 | — | — | EP | disclosed |
| US-20110015438-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE | ARENA PHARMACEUTICALS, INC. | 2011-01-20 | — | — | US | disclosed |
| US-20110015438-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE | ARENA PHARMACEUTICALS, INC. | 2011-01-20 | — | — | US | disclosed |
| US-20110015438-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE | ARENA PHARMACEUTICALS, INC. | 2011-01-20 | — | — | US | disclosed |
| WO-2009111004-A1 | PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE | ARENA PHARMACEUTICALS, INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009111004-A1 | PROCESSES FOR THE PREPARATION OF INTERMEDIATES RELATED TO THE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE | ARENA PHARMACEUTICALS, INC. (US) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015438-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE | HTR2C, HTR3C, HTR3A | CYP51A1 603/4885AOC3 2642/4885TSHR 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.