Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15902708 | 0.77 | CYP2C19 (0.35) | KDM4EALDH1A1CYP2A6CYP2D6CYP2C19 | |
| SCHEMBL10638807 | 0.74 | CHRNB2 (0.44) | KDM4EALDH1A1CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL25629128 | 0.74 | — | — | |
| SCHEMBL8923934 | 0.72 | CHRNB2 (0.56) | KDM4EALDH1A1CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL9712965 | 0.70 | CHRNB2 (0.44) | KDM4EALDH1A1CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL9876261 | 0.70 | ALDH1A1 (0.51) | KDM4EALDH1A1CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL27315459 | 0.68 | KDM4E (0.59) | KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL10650438 | 0.68 | KDM4E (0.59) | KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL27467551 | 0.67 | — | — | |
| SCHEMBL8870395 | 0.67 | ALDH1A1 (1.00) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499987-A1 | Platelet activating factor antagonists | ABBOTT LABORATORIES (US) | 1992-08-26 | — | — | EP | claimed |
| EP-0574494-A4 | INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0574494-A1 | INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1993-12-22 | — | — | EP | disclosed |
| EP-0574494-A1 | INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1993-12-22 | — | — | EP | disclosed |
| WO-1992014732-A1 | INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1992-09-03 | — | — | WO | disclosed |
| WO-1992014732-A1 | INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1992-09-03 | — | — | WO | disclosed |
| EP-0499987-A1 | Platelet activating factor antagonists | ABBOTT LABORATORIES (US) | 1992-08-26 | — | — | EP | disclosed |