Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 14/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 14/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 14/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 14/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 14/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054926 | 0.79 | ALOX15 (0.37) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8497209 | 0.74 | ALDH1A1 (0.36) | ALOX15 | |
| SCHEMBL7830511 | 0.73 | SLC18A3 (0.35) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL16887928 | 0.73 | ALOX15 (0.74) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL14245531 | 0.73 | ALOX15 (0.74) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL29883811 | 0.73 | ALOX15 (0.74) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL15313621 | 0.72 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL16226181 | 0.72 | TSHR (0.37) | — | |
| SCHEMBL14415874 | 0.69 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL23456768 | 0.68 | CHRNB2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600952-A1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | MERCK SHARP & DOHME (GB) | 1994-06-15 | — | — | EP | claimed |
| WO-1993004040-A1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK SHARP & DOHME LIMITED (GB) | 1993-03-04 | — | — | WO | claimed |