Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 10/20 | 0.50 |
| ▸ | MAOB | P27338 | 10/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370260 | 0.87 | KDM4E (0.61) | KDM4EKMT2AMEN1MAPTLMNA | |
| SCHEMBL9376545 | 0.85 | KDM4E (0.52) | KDM4EKMT2AMEN1MAPTLMNA | |
| SCHEMBL9376079 | 0.85 | KMT2A (0.58) | KMT2AMEN1MAPTLMNAMAPK1 | |
| SCHEMBL9370647 | 0.85 | KMT2A (0.54) | KMT2AMEN1MAPTLMNAMAPK1 | |
| SCHEMBL9377156 | 0.85 | ALOX5 (0.46) | KDM4EKMT2AMEN1MAPTLMNA | |
| SCHEMBL9376501 | 0.85 | KMT2A (0.51) | KDM4EKMT2AMEN1MAPTLMNA | |
| SCHEMBL9375923 | 0.85 | MAPT (0.53) | KMT2AMEN1MAPTLMNAMAPK1 | |
| SCHEMBL9371420 | 0.83 | ACHE (0.57) | KDM4EKMT2AMEN1MAPTLMNA | |
| SCHEMBL9370487 | 0.82 | GSTO1 (0.53) | LMNASIRT5ALKKCNQ1 | |
| SCHEMBL9378444 | 0.81 | MAPT (0.46) | KDM4EKMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |