Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377156 | 0.88 | ALOX5 (0.46) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9376079 | 0.88 | KMT2A (0.58) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9376501 | 0.88 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9375923 | 0.88 | MAPT (0.53) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9370487 | 0.87 | GSTO1 (0.53) | LMNAROCK1ALOX5 | |
| SCHEMBL9371420 | 0.86 | ACHE (0.57) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9370494 | 0.86 | LMNA (0.61) | KMT2AMEN1SMN1; SMN2LMNAMMP2 | |
| SCHEMBL9370826 | 0.85 | KDM4E (0.56) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9370896 | 0.84 | KMT2A (0.50) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9373421 | 0.84 | SMN1; SMN2 (0.51) | KMT2AMEN1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |