Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582882 | 0.87 | ALOX5 (0.52) | ALOX5CA12CA1CA2CA7 | |
| SCHEMBL9365201 | 0.87 | ALOX5 (0.43) | ALOX5CHRNB2CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL9022255 | 0.76 | ALOX5 (0.58) | ALOX5GRM5KCNH2 | |
| SCHEMBL9365136 | 0.76 | ALOX5 (0.39) | ALOX5GRM5 | |
| SCHEMBL9229172 | 0.72 | ALOX5 (0.71) | ALOX5CHRNB2CHRNA4CA12CA1 | |
| SCHEMBL9365328 | 0.72 | ALOX5 (0.43) | ALOX5CA12CA1CA2CA7 | |
| SCHEMBL9227260 | 0.72 | ALOX5 (0.53) | ALOX5CHRNB2CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL9224569 | 0.69 | ALOX5 (0.48) | ALOX5CHRNB2CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL9365312 | 0.69 | ALOX5 (0.40) | ALOX5CHRNA3CHRNB4CA12CA1 | |
| SCHEMBL9227008 | 0.68 | CA12 (0.50) | CHRNB2CHRNA3CHRNB1CHRNB4CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375457-B1 | Cyclic ether derivatives | ICI PLC (GB) | 1994-03-16 | — | — | EP | disclosed |
| US-5219881-A | Enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| US-5098932-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC, ICI PHARMA (FR) | 1992-03-24 | — | — | US | disclosed |
| EP-0375457-A2 | Cyclic ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-27 | — | — | EP | disclosed |