Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.71 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.66 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9374202 | 0.84 | ALOX5 (0.73) | ALOX5LTB4RLTB4R2PTGS1PTGS2 | |
| SCHEMBL10693993 | 0.83 | ALOX5 (1.00) | ALOX5LTB4RLTB4R2PTGS1PTGS2 | |
| SCHEMBL10695721 | 0.83 | ALOX5 (0.80) | ALOX5LTB4RLTB4R2FFAR1FFAR4 | |
| SCHEMBL16541044 | 0.83 | LTB4R (0.78) | ALOX5LTB4RLTB4R2PTGS1PTGS2 | |
| SCHEMBL9506981 | 0.82 | ALOX5 (1.00) | ALOX5LTB4RLTB4R2PTGS1PTGS2 | |
| SCHEMBL9373237 | 0.81 | ALOX5 (0.64) | ALOX5LTB4RLTB4R2PTGS1PTGS2 | |
| SCHEMBL16552363 | 0.81 | LTB4R (0.66) | ALOX5LTB4RLTB4R2PTGS1PTGS2 | |
| SCHEMBL13886624 | 0.81 | TAAR1 (0.66) | ALOX5LTB4RLTB4R2FFAR1FFAR4 | |
| SCHEMBL17931580 | 0.80 | LTB4R (0.64) | ALOX5LTB4RLTB4R2PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL17923750 | 0.80 | LTB4R (0.64) | ALOX5LTB4RLTB4R2FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588785-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0588785-A4 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS. | ABBOTT LAB (US) | 1991-12-30 | — | — | EP | disclosed |
| WO-1990012008-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-10-18 | — | — | WO | disclosed |