Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | LMNA | P02545 | 7/20 | 0.60 |
| ▸ | HTT | P42858 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370831 | 0.90 | ACHE (0.55) | MAPTMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL9375112 | 0.90 | MEN1 (0.60) | MAPTMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL9371762 | 0.87 | FAAH (0.62) | MAPTMAPK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9370668 | 0.87 | ALDH1A1 (0.69) | MAPTMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL9370560 | 0.86 | ROCK1 (0.52) | MAPTMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL9371238 | 0.84 | ROCK1 (0.49) | MAPTMAPK1ROCK1ROCK2FAAH | |
| SCHEMBL9373340 | 0.84 | ALDH1A1 (0.67) | MAPTMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL9375833 | 0.84 | ROCK1 (0.53) | MAPTMAPK1ALDH1A1LMNAKMT2A | |
| SCHEMBL9375127 | 0.84 | ROCK1 (0.64) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL9370983 | 0.84 | FAAH (0.53) | MAPTMAPK1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |