Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121664 | 0.85 | TSHR (0.60) | TRPM8MAPTTSHRLMNAHTT | |
| SCHEMBL13870657 | 0.83 | RIPK1 (0.57) | TRPM8MAPTTSHRLMNAHTT | |
| SCHEMBL19459277 | 0.81 | TRPM8 (0.55) | TRPM8MAPTTSHRLMNAHTT | |
| SCHEMBL9584565 | 0.78 | NPC1 (0.41) | TRPM8MAPTTSHRLMNAHTT | |
| SCHEMBL9377352 | 0.77 | ALOX5 (0.60) | TRPM8TSHRPOLBTDP1RIPK1 | |
| SCHEMBL8783435 | 0.77 | TP53 (0.46) | TRPM8MAPTLMNAPOLBTDP1 | |
| SCHEMBL9668325 | 0.73 | RIPK1 (0.57) | TRPM8MAPTTSHRLMNAHTT | |
| SCHEMBL9372657 | 0.73 | RIPK1 (0.47) | TRPM8POLBTDP1RIPK1SMN1; SMN2 | |
| SCHEMBL17882394 | 0.73 | RIPK1 (0.74) | TRPM8POLBTDP1RIPK1 | |
| SCHEMBL9473734 | 0.72 | L3MBTL1 (0.39) | MAPTNPSR1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588785-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-03-30 | — | — | EP | disclosed |
| US-5185363-A | Administering for treatment of inflammatory diseases | ABBOTT LABORATORIES (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0456760-A4 | LIPOXYGENASE INHIBITING COMPOUNDS | — | 1992-01-08 | — | — | EP | disclosed |
| EP-0588785-A4 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS. | ABBOTT LAB (US) | 1991-12-30 | — | — | EP | disclosed |
| EP-0456760-A1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1991-11-21 | — | — | EP | disclosed |
| WO-1990012008-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-10-18 | — | — | WO | disclosed |