Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 12/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369781 | 0.87 | TNK2 (0.42) | TNK2ALDH1A1MAPK7LRRK2 | |
| SCHEMBL10098791 | 0.81 | TNK2 (0.56) | TNK2MAPK7LRRK2 | |
| SCHEMBL9174480 | 0.80 | RAB9A (0.60) | RAB9ALMNAUSP2ALDH1A1CYP1A2 | |
| SCHEMBL16979656 | 0.78 | BRD4 (0.52) | RAB9ALMNAALDH1A1MAPK7LRRK2 | |
| SCHEMBL10391266 | 0.77 | RAB9A (0.69) | RAB9ALMNAUSP2ALDH1A1CYP1A2 | |
| SCHEMBL7852676 | 0.74 | CHEK1 (0.54) | LMNAALDH1A1LRRK2 | |
| SCHEMBL8249206 | 0.71 | CHEK1 (0.54) | TNK2LMNAALDH1A1CHRM2LRRK2 | |
| SCHEMBL9372896 | 0.70 | ALDH1A1 (0.47) | LMNAALDH1A1CHRM2MAPK7LRRK2 | |
| SCHEMBL10391158 | 0.69 | FER (0.55) | CYP1A2LRRK2 | |
| SCHEMBL8790773 | 0.69 | RAB9A (0.53) | RAB9ALMNAUSP2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393530-B1 | 5,11-dihydro-6H-pyrido[2,3,-b][1,4]benzodiazepin-6-ones and -thiones and their use in the prevention or treatment of AIDS | BOEHRINGER INGELHEIM PHARMA (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5087625-A | Pyridodiazepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1992-02-11 | — | — | US | disclosed |
| EP-0393530-A1 | 5,11-dihydro-6H-pyrido[2,3,-b][1,4]benzodiazepin-6-ones and -thiones and their use in the prevention or treatment of AIDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1990-10-24 | — | — | EP | disclosed |