Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | WRN | Q14191 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27968331 | 0.83 | CALM1 (0.58) | LMNACALM1ALDH1A1HPGDALOX5 | |
| SCHEMBL7489744 | 0.81 | CALM1 (0.41) | LMNACALM1ALDH1A1HPGDALOX5 | |
| SCHEMBL27968338 | 0.78 | TP53 (0.48) | LMNACALM1ALDH1A1HPGDALOX5 | |
| (Z)-1,2-Diphenylethene SCHEMBL28198243 | 0.76 | CALM1 (0.44) | LMNACALM1ALDH1A1HPGDALOX5 | |
| SCHEMBL27968429 | 0.74 | LMNA (0.43) | LMNACALM1ALDH1A1HPGDALOX5 | |
| SCHEMBL5108763 | 0.74 | TSHR (0.48) | LMNACALM1ALDH1A1HPGDALOX5 | |
| SCHEMBL1680417 | 0.74 | CYP2A6 (0.53) | LMNACALM1ALDH1A1HPGDALOX5 | |
| SCHEMBL146369 | 0.74 | TP53 (0.61) | LMNACALM1ALDH1A1HPGDALOX5 | |
| SCHEMBL66833 | 0.71 | — | — | |
| SCHEMBL1680416 | 0.71 | TBXAS1 (0.47) | LMNACALM1ALDH1A1HPGDALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588785-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0588785-A4 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS. | ABBOTT LAB (US) | 1991-12-30 | — | — | EP | disclosed |
| WO-1990012008-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-10-18 | — | — | WO | disclosed |