SCHEMBL9375574

SCHEMBL9375574

O=c1[nH]c(C(F)(F)F)c(Br)c(=O)n1-c1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 2/20 0.36
CCND1 P24385 2/20 0.36
CA12 O43570 1/20 0.34
CA9 Q16790 1/20 0.34
HTT P42858 2/20 0.33
BCAT2 O15382 1/20 0.33
BCAT1 P54687 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ENPP3 O14638 1/20 0.33
ENPP1 P22413 1/20 0.33
PSD A5PKW4 4/20 0.32
KCNQ3 O43525 1/20 0.30
KCNQ2 O43526 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9379682 0.73 BCAT1 (0.54) CDK4CCND1BCAT2BCAT1KDM4E
SCHEMBL9376013 0.70 SMN1; SMN2 (0.38) CDK4CCND1CA12CA9HTT
SCHEMBL9376465 0.69 BCAT1 (0.44) CDK4CCND1CA12CA9BCAT2
SCHEMBL9380919 0.68 BCAT2 (0.38) CDK4CCND1BCAT2BCAT1
SCHEMBL9376933 0.64 SMN1; SMN2 (0.38) CDK4CCND1CA12CA9HTT
SCHEMBL11786721 0.64 POLB (0.34) KDM4EENPP3ENPP1
SCHEMBL9376083 0.63 BCAT1 (0.53) CDK4CCND1BCAT2BCAT1KDM4E
SCHEMBL22912544 0.61 HTT (0.40) CA12CA9HTTBCAT2BCAT1
SCHEMBL11252508 0.60 NPBWR1 (0.35) CDK4CCND1HTTPSDKCNQ3
SCHEMBL22495466 0.60 HTT (0.40) HTTBCAT2BCAT1KDM4EKCNQ3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0438209-B1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL IND LTD (JP) 1994-09-21 EP claimed
EP-0438209-A1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1991-07-24 EP claimed
EP-0438209-B1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL IND LTD (JP) 1994-09-21 EP disclosed
US-5116404-A URACIL DERIVATIVES AND PESTICIDES CONTAINING THE SAME AS ACTIVE INGREDIENT NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-05-26 US disclosed
EP-0438209-A1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1991-07-24 EP disclosed