SCHEMBL9376013

SCHEMBL9376013

O=c1cc(Br)[nH]c(=O)n1-c1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.38
CA12 O43570 1/20 0.35
CA9 Q16790 1/20 0.35
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GAA P10253 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
HSD17B10 Q99714 1/20 0.33
HTT P42858 1/20 0.33
CDK4 P11802 3/20 0.32
CCND1 P24385 3/20 0.32
TSHR P16473 1/20 0.32
BCAT1 P54687 2/20 0.32
AKT2 P31751 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9380919 0.83 BCAT2 (0.38) SMN1; SMN2GAACDK4CCND1TSHR
SCHEMBL9376933 0.79 SMN1; SMN2 (0.38) SMN1; SMN2CA12CA9KDM4EALDH1A1
SCHEMBL9379682 0.76 BCAT1 (0.54) SMN1; SMN2KDM4EALDH1A1CDK4CCND1
SCHEMBL6966995 0.61 BCAT1 (0.50) SMN1; SMN2KDM4EALDH1A1BCAT1BCAT2
SCHEMBL10936072 0.59 CA9 (0.46) SMN1; SMN2CA12CA9ALDH1A1KMT2A
SCHEMBL10883634 0.58 MEN1 (0.37) SMN1; SMN2CA12CA9KDM4EALDH1A1
SCHEMBL7454623 0.57 ALDH1A1 (0.56) SMN1; SMN2KDM4EALDH1A1GAAHTT
SCHEMBL465067 0.57 MGLL (0.47) SMN1; SMN2ALDH1A1HSD17B10HTTTSHR
SCHEMBL9188786 0.55 KMT2A (0.44) SMN1; SMN2ALDH1A1GAATSHRKMT2A
SCHEMBL10556241 0.55 NAPRT (0.50) SMN1; SMN2ALDH1A1CDK4CCND1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0438209-B1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL IND LTD (JP) 1994-09-21 EP claimed
EP-0438209-A1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1991-07-24 EP claimed
EP-0438209-B1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL IND LTD (JP) 1994-09-21 EP disclosed
US-5116404-A URACIL DERIVATIVES AND PESTICIDES CONTAINING THE SAME AS ACTIVE INGREDIENT NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-05-26 US disclosed
EP-0438209-A1 Uracil derivatives and pesticides containing the same as active ingredient NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1991-07-24 EP disclosed