Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373865 | 0.90 | F10 (0.33) | F10 | |
| SCHEMBL9372182 | 0.90 | KMT2A (0.36) | ALDH1A1HSD17B10AKT1AKT2HDAC3 | |
| SCHEMBL9371485 | 0.90 | S100A4 (0.37) | F10KDM4EALDH1A1PDK2FGFR1 | |
| SCHEMBL9372114 | 0.87 | ALOX5 (0.40) | F10ALDH1A1SMN1; SMN2PDK2FGFR1 | |
| SCHEMBL10435671 | 0.86 | HDAC3 (0.36) | F10KDM4EALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL9379871 | 0.84 | MAPT (0.41) | KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL9376016 | 0.84 | HRH4 (0.34) | ALDH1A1SMN1; SMN2BRD4BRPF1TSHR | |
| SCHEMBL10435504 | 0.82 | KDM4E (0.36) | F10KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9372466 | 0.81 | HSD11B1 (0.33) | F10KDM4EALDH1A1 | |
| SCHEMBL9372171 | 0.81 | F10 (0.35) | F10KDM4EALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371312-B1 | Benzoxazine derivatives | MERCK PATENT GMBH (DE) | 1994-07-20 | — | — | EP | disclosed |
| US-5036068-A | Cardiovascular disorders | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-07-30 | — | — | US | disclosed |