Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12915446 | 0.87 | MEN1 (0.59) | ASIC3MEN1KMT2ARAB9AADORA2A | |
| SCHEMBL13045285 | 0.85 | MEN1 (0.56) | ASIC3MEN1KMT2ARAB9AADORA2A | |
| SCHEMBL13045288 | 0.83 | MEN1 (0.54) | ASIC3MEN1KMT2ARAB9AADORA2A | |
| SCHEMBL13045287 | 0.81 | MEN1 (0.52) | ASIC3MEN1KMT2ARAB9AADORA2A | |
| SCHEMBL10691587 | 0.81 | BACE1 (0.50) | ASIC3MEN1KMT2ARAB9ABACE1 | |
| SCHEMBL10688965 | 0.81 | RAB9A (0.46) | ASIC3MEN1KMT2ARAB9ABACE1 | |
| SCHEMBL10686271 | 0.80 | MAPT (0.53) | ASIC3MEN1KMT2ARAB9ABACE1 | |
| SCHEMBL3745861 | 0.80 | MEN1 (0.46) | ASIC3MEN1KMT2ARAB9AADORA2A | |
| SCHEMBL22136017 | 0.80 | ASIC3 (0.59) | ASIC3MEN1KMT2ARAB9ABACE1 | |
| SCHEMBL31432891 | 0.80 | ASIC3 (0.59) | ASIC3MEN1KMT2ARAB9ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0387568-B1 | Substituted 1,8-Naphthydridines, process for their preparation and their use as antidotes | BASF AG (DE) | 1994-12-14 | — | — | EP | disclosed |
| US-4720500-A | N-1,8-naphthyridin-2-yl amides useful as immunostimulants | RHONE-POULENC SANTE (FR) | 1988-01-19 | — | — | US | disclosed |