Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM2 | P50570 | 7/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13330001 | 0.93 | DNM2 (0.64) | DNM2MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL12963418 | 0.89 | KMT2A (0.50) | DNM2MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL10811629 | 0.89 | KMT2A (0.49) | DNM2MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL9589312 | 0.87 | DNM2 (0.63) | DNM2MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL2574542 | 0.84 | KMT2A (0.56) | DNM2MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL8349356 | 0.82 | KMT2A (0.54) | MAPK1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16608857 | 0.81 | ALDH1A1 (0.73) | DNM2MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL22228311 | 0.81 | KMT2A (0.73) | MAPK1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12963423 | 0.77 | KMT2A (0.50) | DNM2MAPK1LMNAKMT2AMEN1 | |
| SCHEMBL1194281 | 0.76 | DNM2 (0.78) | DNM2MAPK1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422178-B1 | PYRIMIDINE DERIVATIVES | ZENECA LTD (GB) | 1994-10-05 | — | — | EP | disclosed |
| US-5250548-A | Treating hypertension, heart failure | ABBOTT LABORATORIES (US) | 1993-10-05 | — | — | US | disclosed |
| US-5223505-A | PYRIMIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0422178-A1 | PYRIMIDINE DERIVATIVES. | ICI PLC (GB) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990012790-A1 | PYRIMIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-11-01 | — | — | WO | disclosed |