SCHEMBL937665

SCHEMBL937665

Clc1cc(CN2CCOCC2)ccn1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.54
NCF1 P14598 1/20 0.50
SMN1; SMN2 Q16637 3/20 0.48
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
HPGD P15428 2/20 0.48
TP53 P04637 2/20 0.48
TSHR P16473 2/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
RECQL P46063 1/20 0.47
LOX P28300 1/20 0.47
LOXL3 P58215 1/20 0.47
LOXL2 Q9Y4K0 1/20 0.47
KDR P35968 1/20 0.47
METAP2 P50579 1/20 0.47
PAX8 Q06710 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CYP2A13 Q16696 3/20 0.46
HTT P42858 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL937589 0.85 SMN1; SMN2 (0.54) HRH3SMN1; SMN2RECQLLOXLOXL3
SCHEMBL29944490 0.85 RECQL (0.52) HRH3SMN1; SMN2RECQLLOXLOXL3
SCHEMBL23358024 0.85 RECQL (0.52) HRH3SMN1; SMN2RECQLLOXLOXL3
SCHEMBL31669110 0.85 SMN1; SMN2 (0.54) HRH3SMN1; SMN2RECQLLOXLOXL3
SCHEMBL15265110 0.84 SIGMAR1 (0.63) TSHRRECQLLOXLOXL3LOXL2
SCHEMBL7606866 0.83 SMN1; SMN2 (0.57) HRH3SMN1; SMN2RECQLLOXLOXL3
SCHEMBL17331777 0.81 MC4R (0.54) NCF1NPC1RAB9AHPGDTP53
SCHEMBL2236496 0.81 HRH3 (0.50) HRH3NCF1SMN1; SMN2NPC1RAB9A
SCHEMBL2236500 0.81 NCF1 (0.54) HRH3NCF1SMN1; SMN2NPC1RAB9A
SCHEMBL5255187 0.81 HTT (0.51) HRH3NCF1SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210038607-A1 OXADIAZOLYLTHIOPHENE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS KARUS THERAPEUTICS LIMITED (GB) 2021-02-11 US disclosed
EP-3333157-B1 VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS HARBIN ZHENBAO PHARMACEUTICAL CO LTD (CN) 2020-12-23 EP disclosed
US-10519133-B2 Vinyl compounds as FGFR and VEGFR inhibitors MEDSHINE DISCOVERY INC. (CN) 2019-12-31 US disclosed
EP-3157920-B1 INDOLIZINE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS CHIESI FARM SPA (IT) 2019-08-07 EP disclosed
EP-3157920-B1 INDOLIZINE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS CHIESI FARM SPA (IT) 2019-08-07 EP disclosed
US-20180222886-A1 VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) 2018-08-09 US disclosed
US-20180222886-A1 VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) 2018-08-09 US disclosed
EP-2315761-B1 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LTD (GB) 2018-07-11 EP disclosed
EP-3333157-A1 VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) 2018-06-13 EP disclosed
US-20170260178-A1 ANTIBACTERIAL COMPOUNDS SPERO GYRASE INC (US) 2017-09-14 US disclosed
US-20130252938-A1 Antibacterial Compounds BIOTA EUROPE LTD. (GB) 2013-09-26 US disclosed
WO-2013138860-A1 ANTIBACTERIAL COMPOUNDS BIOTA EUROPE LIMITED (GB) 2013-09-26 WO disclosed
EP-2475657-B1 5-ALKINYLTHIEN-2-YLCARBOXYLIC ACIDS AS INHIBITORS OF FLAVIVIRIDAE VIRUSES GILEAD SCIENCES INC (US) 2013-06-12 EP disclosed
US-8461339-B2 Pharmaceutical compounds SENTINEL ONCOLOGY LIMITED (US) 2013-06-11 US disclosed
US-8461339-B2 Pharmaceutical compounds SENTINEL ONCOLOGY LIMITED (US) 2013-06-11 US disclosed
CN-102471327-A Inhibitors of flaviviridae viruses GILEAD SCIENCES INC 2012-05-23 CN disclosed
US-20110130394-A1 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LIMITED (GB) 2011-06-02 US disclosed
US-20110130394-A1 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LIMITED (GB) 2011-06-02 US disclosed
US-20110020278-A1 INHIBITORS OF FLAVIVIRIDAE VIRUSES GILEAD SCIENCES, INC. (US) 2011-01-27 US disclosed
WO-2010007374-A1 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LIMITED (GB) 2010-01-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170260178-A1 ANTIBACTERIAL COMPOUNDS STS, PGLS, PEPD HRH3 3179/4885NCF1 1356/4885SMN1; SMN2 4614/4885
US-20110130394-A1 PHARMACEUTICAL COMPOUNDS NR2C2, NR3C2, NR0B2 HRH3 166/4885NCF1 971/4885SMN1; SMN2 2784/4885
US-20210038607-A1 OXADIAZOLYLTHIOPHENE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC5, HDAC3 HRH3 70/4885NCF1 530/4885SMN1; SMN2 3345/4885
US-10519133-B2 Vinyl compounds as FGFR and VEGFR inhibitors FGFR1, FLT1, KDR HRH3 3272/4885NCF1 2948/4885SMN1; SMN2 3966/4885
US-20130252938-A1 Antibacterial Compounds STS, PGLS, PEPD HRH3 3179/4885NCF1 1356/4885SMN1; SMN2 4614/4885
US-20110020278-A1 INHIBITORS OF FLAVIVIRIDAE VIRUSES HAVCR2, CYP2F1, CYP4F3 HRH3 4242/4885NCF1 1536/4885SMN1; SMN2 1851/4885
US-20180222886-A1 VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS FGFR1, FLT1, KDR HRH3 3272/4885NCF1 2948/4885SMN1; SMN2 3966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.