Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371231 | 0.89 | NPY5R (0.50) | NPY5RROCK1ROCK2FAAHLMNA | |
| SCHEMBL9373278 | 0.87 | LMNA (0.62) | NPY5RROCK1ROCK2FAAHLMNA | |
| SCHEMBL9370402 | 0.86 | GSTO1 (0.59) | NPY5RROCK1ROCK2FAAHLMNA | |
| SCHEMBL9376530 | 0.84 | ROCK1 (0.51) | NPY5RROCK1ROCK2FAAHLMNA | |
| SCHEMBL9370926 | 0.83 | FAAH (0.64) | NPY5RROCK1ROCK2FAAHLMNA | |
| SCHEMBL9375272 | 0.81 | LMNA (0.60) | NPY5RROCK1ROCK2FAAHLMNA | |
| SCHEMBL9378414 | 0.80 | HDAC3 (0.55) | NPY5RROCK1ROCK2FAAHLMNA | |
| SCHEMBL10967054 | 0.79 | TYR (0.52) | LMNASMN1; SMN2GSTO1MAPTTYR | |
| SCHEMBL9377027 | 0.77 | AR (0.50) | NPY5RROCK1ROCK2LMNASMN1; SMN2 | |
| SCHEMBL9371629 | 0.76 | ABL1 (0.61) | ROCK1ROCK2FAAHLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |