Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.42 |
| ▸ | WNT3A | P56704 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 4/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380207 | 0.89 | TNKS2 (0.36) | TNKS2WNT3ATNKSGUSBMGAM | |
| SCHEMBL9379011 | 0.89 | TNKS2 (0.36) | TNKS2WNT3AMAPK1TNKSGCGR | |
| SCHEMBL9378262 | 0.88 | KMT2A (0.38) | TNKS2TNKSGAAPARP1MEN1 | |
| SCHEMBL9379363 | 0.87 | IDO1 (0.39) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9385136 | 0.86 | BRAF (0.35) | TNKS2WNT3ATNKSPARP1 | |
| SCHEMBL9378535 | 0.86 | IDO1 (0.45) | TNKS2MAPK1TNKSPARP2GUSB | |
| SCHEMBL9379944 | 0.85 | ADORA2B (0.38) | TNKS2WNT3AMEN1ALDH1A1HPGD | |
| SCHEMBL9377862 | 0.85 | CHEK2 (0.38) | TNKS2WNT3AMAPK14 | |
| SCHEMBL9383627 | 0.84 | NPBWR1 (0.40) | TNKS2TNKSPARP1MEN1ALDH1A1 | |
| SCHEMBL9382402 | 0.84 | PTGER3 (0.39) | TNKS2WNT3AMAPK14ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-B1 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | BOEHRINGER MANNHEIM GMBH (DE) | 1994-04-06 | — | — | EP | disclosed |