Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 4/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380207 | 0.88 | TNKS2 (0.36) | PARP1WNT3ATNKS2TNKS | |
| SCHEMBL9378641 | 0.86 | TNKS2 (0.42) | PARP1WNT3ATNKS2TNKS | |
| SCHEMBL9379011 | 0.86 | TNKS2 (0.36) | PARP1WNT3ATNKS2TNKS | |
| SCHEMBL9378262 | 0.85 | KMT2A (0.38) | PARP1TNKS2TNKS | |
| SCHEMBL9379363 | 0.84 | IDO1 (0.39) | — | |
| SCHEMBL9379944 | 0.84 | ADORA2B (0.38) | WNT3ATNKS2 | |
| SCHEMBL9377862 | 0.84 | CHEK2 (0.38) | WNT3ATNKS2TGFBR1 | |
| SCHEMBL9378535 | 0.83 | IDO1 (0.45) | PARP1TNKS2TNKS | |
| SCHEMBL9382402 | 0.81 | PTGER3 (0.39) | WNT3ATNKS2 | |
| SCHEMBL9382394 | 0.81 | WNT3A (0.36) | WNT3ATNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-B1 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | BOEHRINGER MANNHEIM GMBH (DE) | 1994-04-06 | — | — | EP | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |