Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 6/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380207 | 0.87 | TNKS2 (0.36) | ADORA2BADORA2AWNT3ATNKS2 | |
| SCHEMBL9378641 | 0.85 | TNKS2 (0.42) | ALDH1A1HPGDWNT3ATNKS2MEN1 | |
| SCHEMBL9379011 | 0.85 | TNKS2 (0.36) | ADORA2BKDM4EALDH1A1GLAHPGD | |
| SCHEMBL9378262 | 0.85 | KMT2A (0.38) | ADORA2BKDM4EALDH1A1HPGDTNKS2 | |
| SCHEMBL9385136 | 0.84 | BRAF (0.35) | WNT3ATNKS2 | |
| SCHEMBL9382394 | 0.84 | WNT3A (0.36) | WNT3ATNKS2 | |
| SCHEMBL9379363 | 0.84 | IDO1 (0.39) | ALDH1A1HPGDHSD17B10ADORA1ALOX15 | |
| SCHEMBL9377862 | 0.83 | CHEK2 (0.38) | ADORA2BADORA2AWNT3ATNKS2 | |
| SCHEMBL9379057 | 0.79 | BUB1 (0.35) | — | |
| SCHEMBL9381718 | 0.77 | ADH5 (0.43) | CYP2C19TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-B1 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | BOEHRINGER MANNHEIM GMBH (DE) | 1994-04-06 | — | — | EP | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |