Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | CTSS | P25774 | 5/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407184 | 1.00 | CTSK (0.46) | CTSKLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8908677 | 0.86 | CTSK (0.52) | CTSKLMNAMEN1KMT2ACTSS | |
| SCHEMBL9039756 | 0.82 | ALDH1A1 (0.40) | CTSKLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL9038885 | 0.82 | CTSK (0.41) | CTSKLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL20369888 | 0.75 | MAPK8 (0.48) | CTSKLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL11055593 | 0.74 | MEN1 (0.61) | CTSKLMNAMEN1KMT2ACTSS | |
| SCHEMBL9669324 | 0.74 | PTK2 (0.58) | ALDH1A1KDM4E | |
| SCHEMBL11493783 | 0.72 | MAPK8 (0.53) | LMNAMEN1KMT2AALDH1A1HTT | |
| SCHEMBL11655203 | 0.71 | LMNA (0.53) | LMNAMEN1KMT2AALDH1A1HTT | |
| SCHEMBL23604935 | 0.71 | CTSK (0.63) | CTSKLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| US-4959361-A | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists | HOFFMANN-LA ROCHE INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0320992-A2 | Triazolodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |