Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381607 | 0.90 | TDP1 (0.52) | TDP1KDM4EMAPTTSHRPTGDR2 | |
| SCHEMBL20515862 | 0.86 | TSHR (0.48) | TDP1KDM4EMAPTTSHRALOX15 | |
| SCHEMBL9379478 | 0.84 | KDM4E (0.46) | TDP1KDM4EMAPTTSHRALOX15 | |
| SCHEMBL27325060 | 0.82 | TDP1 (0.52) | TDP1KDM4EMAPTTSHRPTGDR2 | |
| SCHEMBL9378807 | 0.81 | ALOX15 (0.66) | TDP1KDM4EMAPTPTGDR2ALOX15 | |
| SCHEMBL9379551 | 0.81 | KCNH2 (0.55) | KDM4EPTGDR2ALOX15ALDH1A1 | |
| SCHEMBL9383560 | 0.80 | PTGDR2 (0.51) | KDM4EPTGDR2 | |
| SCHEMBL9380227 | 0.80 | TDP1 (0.46) | TDP1KDM4EMAPTTSHRPTGDR2 | |
| SCHEMBL19579748 | 0.77 | ALOX15 (0.49) | MAPTTSHRALOX15 | |
| SCHEMBL9379799 | 0.77 | PKM (0.50) | TDP1KDM4EMAPTPTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | claimed |
| EP-0398283-B1 | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |