Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9379799 | 0.78 | PKM (0.50) | PKMPTGDR2ALOX15KDM4EPTGDR | |
| SCHEMBL1611157 | 0.76 | TDP1 (0.49) | PTGDR2ALOX15KDM4ETDP1 | |
| SCHEMBL29567556 | 0.76 | TDP1 (0.49) | PTGDR2ALOX15KDM4ETDP1 | |
| SCHEMBL16832441 | 0.75 | ASPH (0.46) | ALOX15KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9380227 | 0.73 | TDP1 (0.46) | PTGDR2ALOX15KDM4EPTGDRALDH1A1 | |
| SCHEMBL9379821 | 0.72 | KMT2A (0.48) | PTGDR2ALOX15KDM4EALDH1A1HPGD | |
| SCHEMBL9378807 | 0.71 | ALOX15 (0.66) | PKMPTGDR2ALOX15KDM4EALDH1A1 | |
| SCHEMBL9379478 | 0.69 | KDM4E (0.46) | PKMALOX15KDM4EALDH1A1HPGD | |
| SCHEMBL9380983 | 0.69 | KDM4E (0.53) | PKMPTGDR2ALOX15KDM4EALDH1A1 | |
| SCHEMBL9379647 | 0.69 | ALOX15 (0.42) | PTGDR2ALOX15KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | claimed |
| EP-0398283-B1 | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |