Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9290880 | 0.87 | SSTR4 (0.45) | CA2HPGDTSHRSSTR4HTR1A | |
| SCHEMBL7336911 | 0.86 | CA2 (0.43) | CA2HPGDTSHRSSTR4HTR1A | |
| SCHEMBL4197198 | 0.86 | CA2 (0.43) | CA2HPGDTSHRSSTR4HTR1A | |
| SCHEMBL6493103 | 0.84 | GABRA1 (0.47) | CA2HPGDTSHRSSTR4DRD2 | |
| SCHEMBL5695473 | 0.84 | CA2 (0.46) | CA2HPGDTSHRSSTR4HTR1A | |
| SCHEMBL12038566 | 0.81 | CA2 (0.40) | CA2HPGDTSHRSSTR4HTR1A | |
| SCHEMBL12038576 | 0.80 | CA2 (0.39) | CA2HPGDTSHRSSTR4GABRA1 | |
| SCHEMBL7597666 | 0.79 | TSHR (0.54) | CA2HPGDTSHRALDH1A1NPC1 | |
| SCHEMBL7867727 | 0.79 | CYP4F2 (0.45) | CA2HPGDTSHRSSTR4ALDH1A1 | |
| SCHEMBL5695475 | 0.79 | CYP4F2 (0.45) | CA2HPGDTSHRSSTR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |