Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9290880 | 0.87 | SSTR4 (0.45) | GABRA1GABRB2CA2SSTR4MTNR1A | |
| SCHEMBL4197198 | 0.86 | CA2 (0.43) | GABRA1GABRB2CA2SSTR4HPGD | |
| SCHEMBL7336911 | 0.86 | CA2 (0.43) | GABRA1GABRB2CA2SSTR4HPGD | |
| SCHEMBL12038576 | 0.85 | CA2 (0.39) | GABRA1GABRB2CA2SSTR4MTNR1A | |
| SCHEMBL9379705 | 0.84 | CA2 (0.43) | GABRA1GABRB2CA2SSTR4HPGD | |
| SCHEMBL5695473 | 0.84 | CA2 (0.46) | GABRA1GABRB2CA2SSTR4HPGD | |
| SCHEMBL28450234 | 0.84 | GABRA1 (0.56) | GABRA1GABRB2HPGDTSHRHDAC3 | |
| SCHEMBL28450236 | 0.84 | GABRA1 (0.56) | GABRA1GABRB2HPGDTSHRHDAC3 | |
| SCHEMBL7867727 | 0.81 | CYP4F2 (0.45) | CA2SSTR4HPGDTSHRHSD11B1 | |
| SCHEMBL5695475 | 0.81 | CYP4F2 (0.45) | CA2SSTR4HPGDTSHRHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855833-B2 | Methods for producing amino substituted chromanes and intermediates thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-6855833-B2 | Methods for producing amino substituted chromanes and intermediates thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040225137-A1 | Methods for producing amino substituted chromanes and intermediates thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-11-11 | — | — | US | disclosed |
| US-20040225137-A1 | Methods for producing amino substituted chromanes and intermediates thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-11-11 | — | — | US | disclosed |
| US-6756403-B2 | 6-AMINOCHROMAN-2-YL CARBOXYLIC ACIDS AND ESTERS AS PLATELET AGGREGATION INHIBITORS; FROM PHENOL AND KETOGLUTARIC ACID; OR FROM 2-HYDROXYACETOPHENONE AND DIETHYLOXALATE; OR FROM NITROPHENOL AND DIETHYL ESTER OF MALEIC ACID | ELI LILLY AND COMPANY | 2004-06-29 | — | — | US | disclosed |
| US-20040053992-A1 | Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor | ELI LILLY AND COMPANY | 2004-03-18 | — | — | US | disclosed |
| US-20040044225-A1 | Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives | MILLENNIUM PHARMACEUTICALS, INC. | 2004-03-04 | — | — | US | disclosed |
| US-20040014804-A1 | Methods for producing amino-substituted chromanes | ELI LILLY AND COMPANY | 2004-01-22 | — | — | US | disclosed |
| WO-2001094330-A8 | METHODS FOR PRODUCING AMINO SUBSTITUTED CHROMANES | COR THERAPEUTICS INC (US) | 2003-11-06 | — | — | WO | disclosed |
| EP-1292589-A2 | METHODS FOR PRODUCING CHIRAL CHROMONES, CHROMANES, AMINO SUBSTITUTED CHROMANES AND INTERMEDIATES THEREFOR | MILLENIUM PHARMACEUTICALS, INC. (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1286983-A2 | METHODS FOR PRODUCING AMINO-SUBSTITUTED CHROMANES | Eli Lilly & Company (US) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001094330-A3 | METHODS FOR PRODUCING AMINO SUBSTITUTED CHROMANES | COR THERAPEUTICS INC (US) | 2002-08-29 | — | — | WO | disclosed |
| WO-2001094335-A2 | METHODS FOR PRODUCING CHIRAL CHROMONES, CHROMANES, AMINO SUBSTITUTED CHROMANES AND INTERMEDIATES THEREFOR | ELI LILLY & COMPANY (US) | 2001-12-13 | — | — | WO | disclosed |
| WO-2001094331-A2 | METHODS FOR PRODUCING AMINO-SUBSTITUTED CHROMANES | ELI LILLY & COMPANY (US) | 2001-12-13 | — | — | WO | disclosed |
| WO-2001094330-A2 | METHODS FOR PRODUCING AMINO SUBSTITUTED CHROMANES | COR THERAPEUTICS, INC. (US) | 2001-12-13 | — | — | WO | disclosed |
| WO-2001094330-A2 | METHODS FOR PRODUCING AMINO SUBSTITUTED CHROMANES | COR THERAPEUTICS, INC. (US) | 2001-12-13 | — | — | WO | disclosed |
| WO-2001092249-A2 | CHIRAL AND ACHIRAL SYNTHESIS OF 2-ACYL SUBSTITUTED CHROMANES AND THEIR DERIVATIVES | COR THERAPEUTICS, INC. (US) | 2001-12-06 | — | — | WO | disclosed |
| WO-2001087871-A2 | METHODS FOR PRODUCING AMINO SUBSTITUTED CHROMANES AND INTERMEDIATES THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044225-A1 | Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives | ACAT2, ACACA, COASY | GABRA1 888/4885GABRB2 1499/4885CA2 57/4885 |
| US-20040225137-A1 | Methods for producing amino substituted chromanes and intermediates thereof | PFKP, PDGFRA, TBXAS1 | GABRA1 661/4885GABRB2 1545/4885CA2 348/4885 |
| US-20040014804-A1 | Methods for producing amino-substituted chromanes | PFKP, TBXAS1, TBXA2R | GABRA1 272/4885GABRB2 631/4885CA2 324/4885 |
| US-20040053992-A1 | Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor | NOTUM, FAR1, CYP51A1 | GABRA1 281/4885GABRB2 911/4885CA2 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.