Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381350 | 0.87 | ALOX15 (0.55) | ALOX15P2RY12KDM4EMEN1ALDH1A1 | |
| SCHEMBL90018 | 0.86 | ALOX15 (0.53) | ALOX15P2RY12KDM4EPLA2G2AALDH1A1 | |
| SCHEMBL31389258 | 0.85 | ALOX15 (0.52) | ALOX15P2RY12KDM4EPLA2G2ACNR1 | |
| SCHEMBL31389238 | 0.84 | ALOX15 (0.57) | ALOX15P2RY12KDM4EPLA2G2A | |
| SCHEMBL31389291 | 0.84 | ALOX15 (0.51) | ALOX15P2RY12KDM4EALDH1A1KMT2A | |
| SCHEMBL31389266 | 0.82 | ALOX15 (0.55) | ALOX15USP2ALDH1A1 | |
| SCHEMBL31389251 | 0.81 | ALOX15 (0.77) | ALOX15P2RY12KDM4EMEN1ALDH1A1 | |
| SCHEMBL2072605 | 0.81 | ALOX15 (0.77) | ALOX15P2RY12KDM4EMEN1ALDH1A1 | |
| SCHEMBL31389287 | 0.79 | ALOX15 (0.46) | ALOX15P2RY12KDM4EPLA2G2A | |
| SCHEMBL31389256 | 0.78 | ALOX15 (0.50) | ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398283-B1 | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |