Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.58 |
| ▸ | GABRD | O14764 | 2/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.58 |
| ▸ | GABRE | P78334 | 2/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.58 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.58 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.58 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10813064 | 0.87 | GABRP (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8635787 | 0.85 | GABRP (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6907111 | 0.81 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9652547 | 0.81 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30192167 | 0.81 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7951347 | 0.78 | GAA (0.43) | MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL9654342 | 0.76 | GABRP (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL13758178 | 0.76 | TP53 (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2991610 | 0.75 | GABRP (0.78) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1308363 | 0.74 | CYP1A2 (0.59) | MAPTTP53CYP1A2CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| US-4959361-A | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists | HOFFMANN-LA ROCHE INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0320992-A2 | Triazolodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |