Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.76 |
| ▸ | GABRD | O14764 | 2/20 | 0.76 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.76 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.76 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.76 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.76 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.76 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.76 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.76 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.76 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.76 |
| ▸ | GABRE | P78334 | 2/20 | 0.76 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.76 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.76 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.76 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991610 | 0.88 | GABRP (0.78) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8635787 | 0.87 | GABRP (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9380266 | 0.87 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11061295 | 0.86 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7936060 | 0.86 | GABRP (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL31048907 | 0.85 | SMN1; SMN2 (0.69) | CYP1A2CYP2C19MAPK1MAPTLMNA | |
| SCHEMBL11538033 | 0.85 | SMN1; SMN2 (0.69) | CYP1A2CYP2C19MAPK1MAPTLMNA | |
| SCHEMBL11824528 | 0.83 | GABRP (0.71) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30192167 | 0.83 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6907111 | 0.83 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0143016-B1 | DERIVATIVES OF 4-(3-ALKYNYLOXY-2-HYDROXY-PROPYL)-PIPERAZIN-1-YL-N-PHENYL ACETAMIDE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1987-07-29 | — | — | EP | disclosed |
| EP-0143016-A1 | Derivatives of 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-N-phenyl acetamide, their preparation and their therapeutical use | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1985-05-29 | — | — | EP | disclosed |
| US-4476061-A | ANXIOLYTIC AGENTS | PIERRE FABRE, SA (FR) | 1984-10-09 | — | — | US | disclosed |
| US-4409241-A | Method of treating anxiety with 2'-(orthochlorobenzoyl)-4'-chloroglycylanilides, and compositions thereof | PIERRE FABRE S.A. (FR) | 1983-10-11 | — | — | US | disclosed |
| US-4382930-A | 2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and use as medicaments | PIERRE FABRE S.A. (FR) | 1983-05-10 | — | — | US | disclosed |
| US-4380667-A | ANXIOLYTIC AGENTS | PIERRE FABRE S.A. (FR) | 1983-04-19 | — | — | US | disclosed |
| US-4370347-A | Method of treating anxiety with 2'-(orthochlorobenzoyl)-4'-chloroglycylanilides, and compositions thereof | PIERRE FABRE S.A. (FR) | 1983-01-25 | — | — | US | disclosed |
| US-3996209-A | Process for preparing benzodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1976-12-07 | — | — | US | disclosed |