Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.51 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380285 | 0.77 | ACHE (0.47) | ACHELMNACYP3A4 | |
| SCHEMBL9382150 | 0.76 | ACHE (0.51) | ACHEKLK7MAPK1SMN1; SMN2 | |
| SCHEMBL9380049 | 0.73 | ACHE (0.51) | ACHEKLK7 | |
| SCHEMBL9385531 | 0.73 | ACHE (0.39) | ACHEKLK7MAPK1SMN1; SMN2 | |
| SCHEMBL8969094 | 0.68 | ACHE (1.00) | ACHELMNACYP3A4CNR2 | |
| SCHEMBL9382047 | 0.68 | ACHE (0.36) | ACHEKLK7MAPK1SMN1; SMN2 | |
| SCHEMBL8969626 | 0.68 | NOS3 (0.42) | ACHEKLK7SMN1; SMN2TSHR | |
| SCHEMBL8968909 | 0.66 | ACHE (0.97) | ACHELMNACYP3A4CNR2 | |
| SCHEMBL9380862 | 0.66 | ACHE (0.47) | ACHEKLK7MAPK1SMN1; SMN2LMNA | |
| SCHEMBL9381689 | 0.64 | ACHE (0.48) | ACHELMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0597956-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-05-25 | — | — | EP | disclosed |